Jefe de Jefes

Diego Luna

Miguel Ángel Félix Gallardo

José María Yázpik

Amado Carrillo Fuentes

Michael Peña

Enrique 'Kiki' Camarena

Alejandro Edda

Joaquín 'El Chapo' Guzmán

Fernanda Urrejola

María Elvira

Matt Letscher

James 'Jaime' Kuykendall

Tenoch Huerta Mejía

Rafael Caro Quintero

Alyssa Diaz

Mika Camarena

Joaquín Cosío

Ernesto 'Don Neto' Fonseca Carrillo

Ernesto Alterio

Salvador Osuna Nava

Teresa Ruiz

Isabella Bautista

Aaron Staton

Butch Sears

Lenny Jacobson

Roger Knapp

Manuel Masalva

Ramón Arellano Felix

Clark Freeman

Ed Heath

Mark Kubr

Tony

Gerardo Taracena

Pablo Acosta

Scoot McNairy

Narrator (voice) (uncredited)

Memo Villegas

Sammy Álvarez