Super Mouth

Nick Kroll

Nick Birch / Maury the Hormone Monster / Coach Steve / Lola Skumpy / Rick the Hormone Monster (voice)

John Mulaney

Andrew Glouberman (voice)

Jessi Klein

Jessi Glaser (voice)

Jenny Slate

Missy Foreman-Greenwald (voice)

Jason Mantzoukas

Jay Bilzerian (voice)

Maya Rudolph

Diane Birch / Connie the Hormone Monstress (voice)

Fred Armisen

Elliot Birch (voice)

Jordan Peele

Ghost of Duke Ellington (voice)

Andrew Rannells

Matthew (voice)

Jessica Chaffin

Shannon Glaser (voice)

Paul Scheer

Kurt Bilzerian (voice)

Joe Wengert

Caleb / Lump Humpman (voice)

Thandiwe Newton

Mona (voice)

Jak Knight

DeVon (voice)

Heather Lawless

Jenna Bilzerian (voice)

Ali Wong

Ali (voice)

June Diane Raphael

Devin (voice)

Paula Pell

Barbara Glouberman (voice)