D.W. and Dr. Whosit

Bruce Dinsmore

Mr. Read / Binky Barnes / Bailey (voice)

Jodie Resther

Francine Frensky (voice)

Daniel Brochu

Buster Baxter (voice)

Melissa Altro

Muffy Crosswire (voice)

Sonja Ball

Mrs. Read (voice)

Arthur Holden

Mr. Ratburn / Bionic Bunny (voice)

Tracy Braunstein

Baby Kate (voice)

Simon Peacock

Pal (voice)

Tamar Kozlov

Prunella (voice)

Mitchell David Rothpan

George (voice)

Patricia Rodríguez

Sue Ellen Armstrong (voice)

Roman Lutterotti

Arthur Read (voice)

Ethan Pugiotto

D.W. Read (voice)

Evan Blaylock

Alan "The Brain" Powers (voice)

Jake Sim

Tommy Tibble (voice)